Bruno Gridelli, MD
Director,
General Surgery Unit, Liver Transplantation Center
Chairman,
Department of Clinical and Experimental Surgery
Ospedali Riuniti di Bergamo

Largo Barozzi, 1
24127 Bergamo, Italy
Phone: (035) 269390
Fax: (035) 266898
E-mail: bgridelli@ospedaliriuniti.bergamo.it

Education and Training:
1994	Specialization in Pediatric Surgery  (70/70 cum Laude), University of Milan
1993  Registration with the General Medical Council (UK)
1984	Educational Commission for Foreign Medical Graduates certified, USA
1983  Fellowship in transplantation, University of Pittsburgh
1982	Specialization in General Surgery (70/70), University of Milan
1977	Graduation in Medicine and Surgery (110/110 cum Laude), University of Milan

Clinical Experience:
Chairman, Department of Clinical and Experimental Surgery, Ospedali Riuniti di Bergamo.  Coordination and management of the activity of nine surgical divisions including general and thoracic surgery, liver transplantation center,  urology, pediatric surgery, plastic surgery, breast surgery center, maxillo-facial surgery, odontostomatology. June 1999 – present
Director, General Surgery Division and Liver Transplantation Center, Ospedali Riuniti  di Bergamo.  Implementation and development of Italy’s first specifically authorized pediatric liver transplant program.  Performed over 110 liver transplants in the first 3 years of activity.  Received Ministerial authorization to commence an adult liver transplant program in June 1999: performed over 30 adult transplants.  The general surgery activity of the Division consisted of over 2,200 abdominal and thoracic operations, including video-assisted operations.  October 1997 – present
Managing Director, Pediatric Liver Transplantation Program of the Ospedale Maggiore di Milano.
Implementation and development of the first and most active Italian pediatric liver transplant program; performed over 100 pediatric liver transplants.  Hepatobiliary pediatric surgery.  1988 – October 1997
Associate Director, Liver Transplantation Center, Ospedale Maggiore di Milano and Assistant Professor of the Institute of Experimental Surgery, University of Milan.  General and liver transplantation surgery.  Contribution to the development of the adult transplant program which performed about 30 transplants per year.  1986 – October 1997
Fellow in Transplantation, Department of Surgery, University of Pittsburgh, USA.  Multiorgan procurement, liver kidney and pancreas transplantation. 1983-1985
Assistant Professor, Institute of Emergency Surgery, University of Milan.  General and vascular surgery.  Intensive care of the surgical patient. 1980-1983
Research Fellow in gastrointestinal surgery, University of Milan.  Research on esophageal and gastric pathophysiology. 1978-1980

Research Experience: 
1998 – present
Kidney transplantation in the pig with bone-marrow and splenocyte infusion
1994 – 1997
Liver xenotransplantation from sheep to pig: use of FUT75 and polyclonal immunoglobulins to block humoral rejection.  Liver and intestine transplantation in the pig: study of different immunosuppressive protocols.
1991 – 1993
Liver xenotransplantation from Vervet monkey to baboon.  Study of the function, istopathology and ultrastructure of liver xenografts.  Obtained over one year survivals. Study of the effects of Cyclosporine and FK505 on human and baboon lymphocytes. Hepatocyte transplantation in Gunn rats with intrathymic injection of donor antigens.
1986 – 1990
Techniques of organ procurement and preservation.  Multivisceral abdominal transplantation in the pig: procurement technique, early functional results.  Pancreas transplantation in the diabetic pig: functional results, study of immunosuppressive protocols.  Sheep to pig liver xenotransplantation: electron microscopic study of the endothelial cell lining.  Single lung transplantation in the pig: early functional results.
1983 – 1985
Pharmacokynetic and metabolism of cyclosporine in the dog.  Biliary metabolism of cyclosporine in the transplanted liver.
1981 – 1983
Relationship between malnutrition, hormonal profile and immuno-depression in intensive care surgical patients.  Liver transplantation in the pig.  Heart and lung transplantation in the sheep.
1978 – 1981
Experimental and clinical studies of gastrointestinal pathophysiology.  Study of VIP-ergic innervation of the normal and achalasic esophagus.

Academic and Professional Credentials:
1995	Specialization in Pediatric Surgery  (70/70 cum Laude), University of Milan
1993  Registration with the General Medical Council (UK)
1985	Educational Commission for Foreign Medical Graduates certified, USA
1983	Specialization in General Surgery (70/70), University of Milan
1978	Graduation in Medicine and Surgery (110/110 cum Laude), University of Milan

Affiliation to Scientific and Charitable Associations
Member of the International Scientific Advisory Board of the Association for Transplantation Research (ART) of Milan, Not-for-Profit organization which promotes and supports research on transplantation. 1998 to present.
President of Association for Research on Transplant (ART).  1993-1997.

Clinical and Cognitive Interests:
Split-liver transplantation
Multi-organ transplantation
Tolerance Induction 
Xenotransplantation and organ bioengeneering

Selected Publications:
·	Gridelli B, Remuzzi G. Strategies for making more organs available for transplantation. N Engl J Med 2000 Aug 10;343(6):404-10
·	Spada M, Gridelli B, Colledan M, et al. Extensive use of split liver for pediatric liver transplantation: A single-center experience. Liver Transpl 2000 Jul;6(4):415-28
·	Colledan M, Andorno E, Valente U, Gridelli B. A new splitting technique for liver grafts. Lancet 1999 May 22;353(9166):1763
·	Gridelli B, Lucianetti A, Colledan M, et al. Paediatric liver transplantation in Italy. Ital J Gastroenterol 1996 Sep;28(7):396-400
·	Gridelli B, Gatti S, Andreani P, et al. Xenogeneic orthotopic liver transplantation from sheep to pig: delay of rejection by FUT 175 Infusion. Transplant Proc 1996 Apr;28(2):784-7
·	Bonara P, Gridelli B, Galli A, et al. In vitro and in vivo effects of polyclonal human intravenous immunoglobulins in discordant xenotransplantation. Transplant Proc 1996 Apr;28(2):778-83
·	Gridelli B, Gatti S, Piazzini A, et al. Xenogeneic orthotopic liver transplantation in nonhuman primates. Transplant Proc 1993 Feb;25(1 Pt 1):457-61
·	Gridelli B, Gatti S, Piazzini A, et al. Xenogeneic orthotopic liver transplantation from sheep to pig. Transplant Proc 1992 Apr;24(2):614-6
·	Gridelli B, Scanlon L, Pellicci R, et al. Cyclosporine metabolism and pharmacokinetics following intravenous and oral administration in the dog. Transplantation 1986 Mar;41(3):388-91